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Alamar Biosciences Announces Commercial Launch of the ARGO™ HT System and the NULISAseq™ Inflammation Panel 250 for Ultra-high Sensitivity Protein Analysis in Biofluids

ARGO HT System
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  • January 4, 2024

Successful Early Access Program results in purchase orders for 10 systems and installations at 6 institutions in 2023

 

Fremont, CA, US – January 4, 2024 – Alamar Biosciences, a company powering precision proteomics to enable the earliest detection of disease, announced today the commercial launch of the ARGO HT System for push-button, high sensitivity analysis of proteins in biofluids and the NULISAseq Inflammation Panel 250 for deep profiling of immune response. The ARGO HT System provides an automated method for running NULISA™ assays with less than 30 minutes of total hands-on time, reducing the variability seen with manual assay technologies while freeing up researchers’ precious time. The launch of these two products represents an important milestone in the company’s goal to deliver high sensitivity, high plex protein analysis to support the discovery and translation of critical biomarkers involved in disease progression and therapeutic response.

“We are thrilled to bring this game-changing platform to the market as it solves a huge unmet need in biomarker analysis for an automated solution for high sensitivity, multiplexed detection of proteins,” said Dr. Yuling Luo, Founder, Chairman and CEO of Alamar. “Last year we completed over 80 technology access projects and researchers’ response to the data has been overwhelmingly positive. We have already received 10 purchase orders from participants in our early access program and have completed successful instrument placements at 6 sites within the US.”

Chronic inflammation is implicated in the development of many diseases including autoimmune disorders, neurodegenerative diseases, cardiovascular disease, and cancer. Measuring cytokines and other biomarkers of immune activation is particularly important for not only understanding the underlying mechanisms of disease but in predicting progression and developing targeted therapies. Unfortunately, existing technologies lack the sensitivity to detect critical low abundance cytokines or the broad dynamic range to comprehensively measure inflammatory biomarkers present in plasma and other biofluids.

In a recent publication, the NULISA platform detected important biomarkers at 250-fold higher sensitivity than other commercially available high multiplex immunoassay platforms (Nature Communications). With the ability to measure 12 logs of dynamic range, NULISA assays can detect proteins across the biological spectrum within a single assay reaction, improving workflow while preserving precious samples.

“We are extremely excited to have the ARGO HT System installed and running research projects in our lab. This technology provides the scientific community with a cost-effective option for comprehensive analysis of the immune system,” said Dr. Holden Maecker, Director of the Human Immune Monitoring Center at Stanford University. “I was especially impressed with the simplicity of the system and how quickly my team was able to become proficient. Within a week, we were able to reproduce the excellent results generated by Alamar on samples from our IMPACC study, further demonstrating the robustness of the system and NULISA assay across different users and labs.”

About Alamar Biosciences, Inc.

Alamar Biosciences is a privately held life sciences company with a mission to power precision proteomics to enable the earliest detection of disease. The company’s proprietary NULISA Platform along with the ARGO HT System work seamlessly with the latest advances in genomics to achieve single digit attomolar detection sensitivity, greatly surpassing the most sensitive protein detection technology on the market today. For more information, please visit https://www.alamarbio.com.

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Steve Williams, MD, PhD

CSO

Dr. Willams serves as the company’s Chief Scientific Officer. He was previously Chief Medical Officer at Standard Biotools and at SomaLogic where he pioneered the discipline for discovery and validation of predictive, diagnostic and prognostic models using machine-learning applied to large-plex proteomics. 20 such tests were used for drug characterization, safety and efficacy when incorporated in clinical drug trials at Pharma/Biotech and 17 different multivariate tests were validated and translated into regulated healthcare uses. Prior to SomaLogic, Dr. Williams was at Pfizer in the UK and the USA as a clinical triallist in Translational Medicine, and subsequently as VP, Global Clinical Technology. He sat on the National Advisory Council for the National Institute of Biomedical Imaging and Bioengineering, the Executive Committee for the FNIH Biomarkers Consortium, and worked with FDA and PhRMA on developing evidentiary standards for biomarker qualification. Dr. William’s medical training was in London, at Charing Cross and Westminster Medical School, followed by a PhD in medicine/physiology at the same institution and training in Radiology at the University of Newcastle Upon Tyne. Steve is co-inventor on 26 proteomics patents and author/coauthor on multiple foundational proteomics manuscripts.

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Justin McAnear

CFO

Mr. McAnear serves as the company’s Chief Financial Officer. He brings over 25 years of operational and financial leadership experience across various sectors and was instrumental in taking 10x Genomics public in 2019, serving as its CFO for over five years. Mr. McAnear served for over 3 years as Tesla’s VP of Worldwide Finance and Operations, supporting landmark initiatives such as the Model X and Model 3 launches and Solar City acquisition.  He also held various roles at Apple and J&J earlier in his career and served as a naval officer and aviator for over 9 years.