Back to News​
Press Release

Alamar Biosciences Announces the Commercial Launch of Ultra-high Sensitivity NULISAseq™ CNS Disease Panel 120 and NULISAqpcr™ pTau-217 Assays

Back to Publications​
  • March 5, 2024

Data demonstrating the superior performance over existing assays highlighted at the Alzheimer’s Disease and Parkinson’s Disease (AD/PD™ 2024) international conference in Lisbon, Portugal.

Fremont, CA, US – Alamar Biosciences, a company powering precision proteomics to enable the earliest detection of disease, announced today the commercial launch of the NULISAseq CNS Disease Panel 120 for highly multiplexed protein analysis of all the critical pathways implicated in major neurological disorders, and the NULISAqpcr pTau-217 Assay (ALZpath antibody) for focused studies of this important biomarker in dementia research.  Both assays benefit from the unparalleled sensitivity of the NULISA™ chemistry and are run on the fully automated ARGO™ HT System that streamlines the time to complete large cohort studies. The launch of these two products represents another important milestone in the company’s goal to deliver high-sensitivity protein analysis from biofluids to enable earlier diagnosis of disease and better prediction of therapeutic outcomes. The products are expected to ship in Q2 2024. 

“We are very pleased to bring these tools to the market as they represent the culmination of a close partnership with the neuroscience community,” said Dr. Yuling Luo, Founder, Chairman & CEO of Alamar. “This “first-in-class” panel content was provided by leading researchers in pharma and academia who were looking for a more comprehensive way to look at CNS diseases while maintaining the high sensitivity required to detect critical biomarkers in plasma and CSF. We have also partnered with ALZpath, Inc. to bring the performance of their industry standard pTau217 antibody to a new level of sensitivity.”

The rising incidence of neurodegenerative diseases in our aging population has propelled research initiatives to better understand the disease pathology and develop new therapeutic targets. This research depends on the availability of biomarkers to detect disease earlier and distinguish between highly related dementia disorders. Recently, the pTau217 protein has been proven to be an important biomarker in Alzheimer’s Disease; however, due to its low abundance in plasma, it requires a highly sensitive detection method to measure it from clinically accessible sample types.

“The Alamar products represent a significant advancement in Alzheimer’s Disease research by providing the sensitivity to detect critical biomarkers from as little as 10uL blood or CSF,” said Henrik Zetterberg, MD, PhD, Professor and Chief Physician at the Institute of Neuroscience and Physiology at the University Gothenburg, Sweden. “I’m especially excited about their ability to measure low abundant biomarkers from dried blood spots, a standard collection method that can be done in one’s home and really opens the possibility for early screening of the disease.” Dr. Zetterberg will be presenting data on the assay’s performance at the upcoming AD/PD 2024 international conference, Wednesday, March 6, 1-1:30pm GMT: Biofluid-based biomarkers for Alzheimer’s Disease and related disorders – precision, panels and patterns.

About Alamar Biosciences, Inc.

Alamar Biosciences is a privately held life sciences company with a mission to power precision proteomics to enable the earliest detection of disease. The company’s proprietary NULISA Platform along with the ARGO HT System work seamlessly with the latest advances in genomics to achieve single digit attomolar detection sensitivity, greatly surpassing the most sensitive protein detection technology on the market today. For more information, please visit alamarbio.com.

Linkedin

Steve Williams, MD, PhD

CSO

Dr. Willams serves as the company’s Chief Scientific Officer. He was previously Chief Medical Officer at Standard Biotools and at SomaLogic where he pioneered the discipline for discovery and validation of predictive, diagnostic and prognostic models using machine-learning applied to large-plex proteomics. 20 such tests were used for drug characterization, safety and efficacy when incorporated in clinical drug trials at Pharma/Biotech and 17 different multivariate tests were validated and translated into regulated healthcare uses. Prior to SomaLogic, Dr. Williams was at Pfizer in the UK and the USA as a clinical triallist in Translational Medicine, and subsequently as VP, Global Clinical Technology. He sat on the National Advisory Council for the National Institute of Biomedical Imaging and Bioengineering, the Executive Committee for the FNIH Biomarkers Consortium, and worked with FDA and PhRMA on developing evidentiary standards for biomarker qualification. Dr. William’s medical training was in London, at Charing Cross and Westminster Medical School, followed by a PhD in medicine/physiology at the same institution and training in Radiology at the University of Newcastle Upon Tyne. Steve is co-inventor on 26 proteomics patents and author/coauthor on multiple foundational proteomics manuscripts.

Linkedin

Justin McAnear

CFO

Mr. McAnear serves as the company’s Chief Financial Officer. He brings over 25 years of operational and financial leadership experience across various sectors and was instrumental in taking 10x Genomics public in 2019, serving as its CFO for over five years. Mr. McAnear served for over 3 years as Tesla’s VP of Worldwide Finance and Operations, supporting landmark initiatives such as the Model X and Model 3 launches and Solar City acquisition.  He also held various roles at Apple and J&J earlier in his career and served as a naval officer and aviator for over 9 years.