NULISAqpcr™ NfL Assay

From Injury to Insight.

Achieve higher precision of NfL detection across disease types

Neurofilament light (NfL) is a structural protein in neurons that supports axons and aids transport. When axons are damaged, NfL is released into CSF and blood. Elevated NfL levels indicate neuronal injury and serve as a biomarker for diagnosing and monitoring neurological diseases such as  Amyotrophic Lateral Sclerosis, Alzheimer’s Disease, Parkinson’s Disease, Multiple Sclerosis, Traumatic Brain Injury and stroke.

The NULISAqpcr™ NfL Assay delivers precise detection of neurofilament light protein in serum or plasma using just 10 µL* of sample. Its analytical performance is rigorously validated, ensuring exceptional accuracy and confidence in every result.

*Sample input volumes vary. Please see product manual for details.

Quantify More with fg/mL Sensitivity

A 7-point standard curve enables absolute quantitation of NfL.
NEFL_StdCurve-01

Unmatched
Sensitivity

Attomolar sensitivity to provide biologically meaningful insights for early neuroaxonal injury detection and early diseases monitoring

Broad
Dynamic Range

Expanded dynamic range to enable detection of NfL across full range of biological concentrations

Automated
Workflow

Fully automated workflows with under 30 minutes hands-on time using the ARGO HT System

Precise
Quantitation

Absolute quantitation of NfL in serum and plasma samples

Publication

Head-to-head comparison of plasma p-tau217 immunoassays for incipient Alzheimer’s disease in community cohorts

Read the publication

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Steve Williams, MD, PhD

CSO

Dr. Willams serves as the company’s Chief Scientific Officer. He was previously Chief Medical Officer at Standard Biotools and at SomaLogic where he pioneered the discipline for discovery and validation of predictive, diagnostic and prognostic models using machine-learning applied to large-plex proteomics. 20 such tests were used for drug characterization, safety and efficacy when incorporated in clinical drug trials at Pharma/Biotech and 17 different multivariate tests were validated and translated into regulated healthcare uses. Prior to SomaLogic, Dr. Williams was at Pfizer in the UK and the USA as a clinical triallist in Translational Medicine, and subsequently as VP, Global Clinical Technology. He sat on the National Advisory Council for the National Institute of Biomedical Imaging and Bioengineering, the Executive Committee for the FNIH Biomarkers Consortium, and worked with FDA and PhRMA on developing evidentiary standards for biomarker qualification. Dr. William’s medical training was in London, at Charing Cross and Westminster Medical School, followed by a PhD in medicine/physiology at the same institution and training in Radiology at the University of Newcastle Upon Tyne. Steve is co-inventor on 26 proteomics patents and author/coauthor on multiple foundational proteomics manuscripts.

Justin McAnear

CFO

Mr. McAnear serves as the company’s Chief Financial Officer. He brings over 25 years of operational and financial leadership experience across various sectors and was instrumental in taking 10x Genomics public in 2019, serving as its CFO for over five years. Mr. McAnear served for over 3 years as Tesla’s VP of Worldwide Finance and Operations, supporting landmark initiatives such as the Model X and Model 3 launches and Solar City acquisition.  He also held various roles at Apple and J&J earlier in his career and served as a naval officer and aviator for over 9 years.