The broadest coverage of cytokine and chemokines of any available neurology panel.
The identification of informative protein biomarkers for neurodegenerative disorders is critical to the development of better therapeutic options and improved patient outcomes. Highly sensitive, multiplexed analysis of both neuro-specific proteins and the inflammatory response from plasma and CSF provides scientists the power to
detect important biomarkers such as pTau-217, GFAP and alpha-synuclein, as well as measure changes in the key inflammatory pathways. The NULISASeq™ CNS Disease Panel provides robust analysis of 120+ proteins to support protein biomarker discovery and validation studies.
Preliminary Content (final content subject to change)
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| Gene (Other) | Full Gene Name | Uniprot ID |
|---|---|---|
| BDNF | Brain Derived Neurotrophic Factor | P23560 |
| CCL11 (Eotaxin) | C-C Motif Chemokine Ligand 11 | P51671 |
| CCL13 (ΜCP-4) | C-C Motif Chemokine Ligand 13 | Q99616 |
| CCL17 (TARC) | C-C Motif Chemokine Ligand 17 | Q92583 |
| CCL2 (MCP-1) | C-C Motif Chemokine Ligand 2 | P13500 |
| CCL22 (MDC) | C-C Motif Chemokine Ligand 22 | O00626 |
| CCL26 (Eotaxin-3) | C-C Motif Chemokine Ligand 26 | Q9Y258 |
| CCL3 (MIP-1α) | C-C Motif Chemokine Ligand 3 | P10147 |
| CCL4 (MIP-1β) | C-C Motif Chemokine Ligand 4 | P13236 |
| CD40LG (CD40 ligand) | CD40 Ligand | P29965 |
| CHI3L1 (YKL-40) | Chitinase 3 Like 1 | P36222 |
| CRP | C-Reactive Protein | Q5VVP7 |
| CSF2 (GM-CSF) | Colony Stimulating Factor 2 | P04141 |
| CX3CL1 (Fractalkine) | C-X-C Motif Chemokine Ligand 1 | P78423 |
| CXCL1 (GROα) | C-X-C Motif Chemokine Ligand 1 | P09341 |
| CXCL10 (IP-10) | C-X-C Motif Chemokine Ligand 10 | P02778 |
| CXCL8 (IL-8) | C-X-C Motif Chemokine Ligand 8 | P10145 |
| FGF2 (FGF2) | Fibroblast Growth Factor 2 | P09038 |
| FLT1 | Fms Related Receptor Tyrosine Kinase 1 | P17948 |
| GFAP | Glial Fibrillary Acidic Protein | P14136 |
| IFNG (IFN-γ) | Interferon Gamma | P01579 |
| IL-10 | Interleukin 10 | P22301 |
| IL-12A|IL-12B (IL-12P35) | Interleukin 12A | Interleukin 12B | P29459|P29460 |
| IL-13 | Interleukin 13 | P35225 |
| IL-15 | Interleukin 15 | P40933 |
| IL-16 | Interleukin 16 | Q14005 |
| IL-17A | Interleukin 17A | Q16552 |
| IL-18 | Interleukin 18 | Q14116 |
| IL-1A | Interleukin 1 Alpha | P01583 |
| IL-1B | Interleukin 1 Beta | P01584 |
| IL-2 | Interleukin 2 | P60568 |
| IL-33 | Interleukin 33 | O95760 |
| IL-4 | Interleukin 4 | P05112 |
| IL-5 | Interleukin 5 | P05113 |
| IL-6 | Interleukin 6 | P05231 |
| IL-6R | Interleukin 6 Receptor | P08887 |
| IL-7 | Interleukin 7 | P13232 |
| IL-9 | Interleukin 9 | P15248 |
| KDR (VEGFR-2) | Kinase Insert Domain Receptor | P35968 |
| LTA (TNF-β) | Lymphotoxin Alpha | P01374 |
| NGF (β-NGF) | Nerve Growth Factor | P01138 |
| PGF (PIGF) | Placental Growth Factor | P49763 |
| S100A12 (ENRAGE) | S100 Calcium Binding Protein A12 | P80511 |
| TEK (TIE-2) | TEK Receptor Tyrosine Kinase | Q02763 |
| TNF (TNF-α) | Tumor Necrosis Factor | P01375 |
| TREM-1 | Triggering Receptor Expressed On Myeloid Cells 1 | Q9NP99 |
| VCAM-1 | Vascular Cell Adhesion Molecule 1 | P19320 |
| VEGF-A | Vascular Endothelial Growth Factor A | P15692 |
| VEGF-D | Vascular Endothelial Growth Factor D | O43915 |
| VSNL1 (VILIP) | Visinin Like 1 | P62760 |
| A2M | Alpha-2-Macroglobulin | P01023 |
| ACHE | Acetylocholinesterase (Cartwright Blood Group) | P22303 |
| AGRN | Agrin | O00468 |
| AHSG | Alpha 2-HS Glycoprotein | P02765 |
| ANG | Angiogenin | P03950 |
| ANXA5 | Annexin A5 | P08758 |
| APOE | Apolipoprotein E | P02649 |
| Abeta38 | Amyloid Beta Precursor Protein | P05067 |
| Abeta40 | Amyloid Beta Precursor Protein | P05067 |
| Abeta42 | Amyloid Beta Precursor Protein | P05067 |
| ATXN2 | Ataxin 2 | Q99700 |
| BACE1 | Beta-Secretase 1 | P56817 |
| BASP1 | Brain Abundant Membrane Attached Signal Protein 1 | P80723 |
| CALB2 | Calbindin 2 | P22676 |
| CD63 | CD63 Molecule | P08962 |
| CDK5 | Cyclin Dependent Kinase 5 | Q00535 |
| CFH | Complement Factor H | P08603 |
| CHIT1 | Chitinase 1 | Q13231 |
| CLU | Clusterin | P10909 |
| CNTN2 | Contactin 2 | Q02246 |
| CRH | Corticotropin Releasing Hormone | P06850 |
| CST3 | Cystatin 3 | P01034 |
| ENO2 | Enolase 2 | P09104 |
| FABP3 | Fatty Acid Binding Protein 3 | P05413 |
| FCN2 | Ficolin 2 | Q15485 |
| FOLR1 | Folate Receptor Alpha | P15328 |
| GAP43 | Growth Associated Protein 43 | P17677 |
| GDNF | Glial Cell Derived Neurotrophic Factor | P39905 |
| GOT1 | Glutamic-Oxaloacetic Transaminase 1 | P17174 |
| HBA1; HBA2 | Hemoglobin Subunit Alpha 1 | P69905 |
| ICAM1 | Intercellular Adhesion Molecule 1 | P05362 |
| IGF1 | Insulin Like Growth Factor 1 | P05019 |
| IGFBP7 | Insulin Like Growth Factor Binding Protein 7 | Q16270 |
| KLK6 | Kallikrein Related Peptidase 6 | Q92876 |
| LRRK2 | Leucine Rich Repeat Kinase 2 | Q5S007 |
| MAP1LC3A | Microtubule Associated Protein 1 Light Chain 3 Alpha | Q9H492 |
| p-tau181 | Microtubule Associated Protein Tau | P10636 |
| p-tau217 | Microtubule Associated Protein Tau | P10636 |
| p-tau231 | Microtubule Associated Protein Tau | P10636 |
| T-tau | Microtubule Associated Protein Tau | P10636 |
| MDH1 | Malate Dehydrogenase 1 | P40925 |
| MME | Membrane Metalloendopeptidase | P08473 |
| MSLN | Mesothelin | Q13421 |
| NCAM1 | Neural Cell Adhesion Molecule 1 | P13591 |
| NEFH | Neurofilament Heavy Chain | P12036 |
| NEFL | Neurofilament Light Chain | P07196 |
| NPTX1 | Neuronal Pentraxin 1 | Q15818 |
| NPTX2 | Neuronal Pentraxin 2 | P47972 |
| NPTXR | Neuronal Pentraxin Receptor | O95502 |
| NPY | Neuropeptide Y | P01303 |
| NRGN | Neurogranin | Q92686 |
| PARK7 | Parkinsonism Associated Deglycase | Q99497 |
| PDGFRB | Platelet Derived Growth Factor Receptor Beta | P09619 |
| PDLIM5 (PD-L1) | PDZ And LIM Domain 5 | Q96HC4 |
| PGK1 | Phosphoglycerate Kinase 1 | P00558 |
| POSTN | Periostin | Q15063 |
| PRDX6 | Peroxiredoxin 6 | P30041 |
| PSEN1 | Presenilin 1 | P49768 |
| PTN | Pleiotrophin | P21246 |
| REST | RE1 Silencing Transcription Factor | Q13127 |
| RUVBL2 | RuvB Like AAA ATPase 2 | Q9Y230 |
| S100B | S100 Calcium Binding Protein B | P04271 |
| SAA1 | Serum Amyloid A1 | P0DJI8 |
| SFRP1 | Secreted Frizzled Related Protein 1 | Q8N474 |
| SLIT2 | Slit Guidance Ligand 2 | O94813 |
| SNAP25 | Synaptosome Associated Protein 25 | P60880 |
| SNCA | Synuclein Alpha | P37840 |
| SOD1 | Superoxide Dismutase 1 | P00441 |
| SQSTM1 | Sequestosome 1 | Q13501 |
| TAFA5 | TAFA Chemokine Family Member 5 | Q7Z5A7 |
| TARDBP | TAR DNA Binding Protein | Q13148 |
| TIMP3 | TIMP Metallopeptidase Inhibitor 3 | P35625 |
| TREM2 | Triggering Receptor Expressed on Myeloid Cells 2 | Q9NZC2 |
| UBB | Ubiquitin B | P0CG47 |
| UCHL1 | Ubiquitin C-Terminal Hydrolase L1 | P09936 |
| YWHAG | Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma | P61981 |
| YWHAZ | Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta | P63104 |
Partner with our Assay Services Team to customize your panel with the addition of customer-defined proprietary or commercially available antibodies.
Learn more about the ultra-high sensitivity NULISA™ chemistry.
Up to 10 customer defined assays can be added to pre-existing NULISAseq panels.
FOR RESEARCH USE ONLY. Not for use in diagnostic procedures.
Looking for more information? Contact us today and a representative will reach out to you soon.
Alamar Biosciences, Inc.
47071 Bayside Pkwy
Fremont, CA 94538
1 (510) 626-9888
Fax: (510) 605-5062
