The coming era of proteomics-driven precision medicine

Topic/Product:
NULISA, Technology
Disease Area:
Technology
Sample Type:
Plasma

Abstract

The concept of ‘Proteomics-Driven Precision Medicine’ highlighted in 2019, emphasized the potential of proteomics to transform precision medicine by offering deeper insights into dynamic biological processes. Since then, this field has seen remarkable advancements, interlinking with key pillars such as protein expression profiling, post-translational modifications, protein-protein interactions, and spatial proteomics to transform healthcare. Technological progress has led to the creation of comprehensive reference maps of proteomes, identification of over 90% of human protein-coding genes, and detailed cellular and molecular landscapes within organs. Proteomics has significantly advanced health monitoring and disease surveillance by developing aging models, predicting disease risks with superior protein risk scores, identifying biomarkers for early conditions like dementia, and securing FDA approval for multiple cancer biomarkers. By providing deeper insights into the proteome’s complexity and dynamics, proteomics is revolutionizing our understanding, diagnosis, and treatment of diseases, firmly establishing itself as a cornerstone of precision medicine.

Authors & Affiliations

Ying Jiang , Jian Wang , Aihua Sun , Hongxing Zhang , Xiaobo Yu , Weijie Qin , Wantao Ying , Yanchang Li , Cheng Chang , Xiaowen Wang , Linhai Xie , Wei Liu , Jialin Liu , Xiaomei Zhang , Qunjiao Yan , Yu Zou , Chuanping Zhao , Haofan Sun , Jian Zhang , Shicheng Su , Qiang Gao , Fuchu He

1 State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China. 2 International Academy of Phronesis Medicine (Guangdong), Guangdong, China. 3 Institute of Health Service and Transfusion Medicine, Beijing, China. 4 State Key Laboratory of Medical Proteomics, Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. 5 Department of Liver Surgery and Transplantation, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.

Steve Williams, MD, PhD

CSO

Dr. Willams serves as the company’s Chief Scientific Officer. He was previously Chief Medical Officer at Standard Biotools and at SomaLogic where he pioneered the discipline for discovery and validation of predictive, diagnostic and prognostic models using machine-learning applied to large-plex proteomics. 20 such tests were used for drug characterization, safety and efficacy when incorporated in clinical drug trials at Pharma/Biotech and 17 different multivariate tests were validated and translated into regulated healthcare uses. Prior to SomaLogic, Dr. Williams was at Pfizer in the UK and the USA as a clinical triallist in Translational Medicine, and subsequently as VP, Global Clinical Technology. He sat on the National Advisory Council for the National Institute of Biomedical Imaging and Bioengineering, the Executive Committee for the FNIH Biomarkers Consortium, and worked with FDA and PhRMA on developing evidentiary standards for biomarker qualification. Dr. William’s medical training was in London, at Charing Cross and Westminster Medical School, followed by a PhD in medicine/physiology at the same institution and training in Radiology at the University of Newcastle Upon Tyne. Steve is co-inventor on 26 proteomics patents and author/coauthor on multiple foundational proteomics manuscripts.

Justin McAnear

CFO

Mr. McAnear serves as the company’s Chief Financial Officer. He brings over 25 years of operational and financial leadership experience across various sectors and was instrumental in taking 10x Genomics public in 2019, serving as its CFO for over five years. Mr. McAnear served for over 3 years as Tesla’s VP of Worldwide Finance and Operations, supporting landmark initiatives such as the Model X and Model 3 launches and Solar City acquisition.  He also held various roles at Apple and J&J earlier in his career and served as a naval officer and aviator for over 9 years.