- July 14, 2025
- Fuchu He, et al. Bejing Institute of Lifeomics
Topic/Product:
NULISA, Technology
Disease Area:
Technology
Sample Type:
Plasma
Abstract
The concept of ‘Proteomics-Driven Precision Medicine’ highlighted in 2019, emphasized the potential of proteomics to transform precision medicine by offering deeper insights into dynamic biological processes. Since then, this field has seen remarkable advancements, interlinking with key pillars such as protein expression profiling, post-translational modifications, protein-protein interactions, and spatial proteomics to transform healthcare. Technological progress has led to the creation of comprehensive reference maps of proteomes, identification of over 90% of human protein-coding genes, and detailed cellular and molecular landscapes within organs. Proteomics has significantly advanced health monitoring and disease surveillance by developing aging models, predicting disease risks with superior protein risk scores, identifying biomarkers for early conditions like dementia, and securing FDA approval for multiple cancer biomarkers. By providing deeper insights into the proteome’s complexity and dynamics, proteomics is revolutionizing our understanding, diagnosis, and treatment of diseases, firmly establishing itself as a cornerstone of precision medicine.
Authors & Affiliations
Ying Jiang , Jian Wang , Aihua Sun , Hongxing Zhang , Xiaobo Yu , Weijie Qin , Wantao Ying , Yanchang Li , Cheng Chang , Xiaowen Wang , Linhai Xie , Wei Liu , Jialin Liu , Xiaomei Zhang , Qunjiao Yan , Yu Zou , Chuanping Zhao , Haofan Sun , Jian Zhang , Shicheng Su , Qiang Gao , Fuchu He
1 State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China. 2 International Academy of Phronesis Medicine (Guangdong), Guangdong, China. 3 Institute of Health Service and Transfusion Medicine, Beijing, China. 4 State Key Laboratory of Medical Proteomics, Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. 5 Department of Liver Surgery and Transplantation, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
