As blood-based biomarkers continue to reshape the landscape of Alzheimer disease (AD) diagnosis and research, advances in highly sensitive detection technologies are enabling researchers to investigate a broader range of disease-related pathologies. Among these emerging markers is extracellular mid-region tau (eMTBR-tau), a fragment of tau associated with the seeding and formation of neurofibrillary tangles that may provide complementary information to established biomarkers such as phosphorylated tau.
At the 2026 Alzheimer’s Association International Conference (AAIC) in London, NeurologyLive® spoke with Stephen Williams, PhD, chief scientific officer at Alamar Biosciences, about the company’s approach to biomarker development and the evolving role of blood-based testing in neurologic disease. The conversation touched on the development of eMTBR-tau testing, the potential of multiplex approaches to characterize multiple disease pathologies, and the challenges of translating increasingly complex biomarker data into clinically useful tools…
